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What’s the Big Deal?

AIDS-related complications and deaths are declining, while heart disease among people with HIV is emerging as a major public health problem. This is happening despite effective treatment for HIV. People with HIV are 50 to 100% more likely to develop heart disease — this includes heart attack and stroke — compared with people who do not have HIV. Increased chronic inflammation related to HIV may be contributing to the increased risk of heart disease.

What’s Being Done about Heart Disease in HIV?

REPRIEVE, which stands for a Randomized Trial to Prevent Vascular Events in HIV, is the first large-scale randomized clinical research trial to test a strategy for heart disease prevention among people living with HIV. Specifically, REPRIEVE will test whether a daily dose of a statin (pitavastatin) reduces the risk of heart disease among HIV-infected individuals.

What are Statin Medications?

In people without HIV, statin medications reduce cholesterol and prevent heart disease. In smaller studies among people with HIV, statins have also to decreased inflammation; we need to confirm these findings in larger studies of people with HIV.

Participants in REPRIEVE will be randomized to receive Pitavastatin Calcium (Livalo) or a placebo pill.

Pitavastatin Calcium (Livalo) is a statin that is approved by the FDA, and based on current information, Pitavastatin Calcium (Livalo) is considered safe for use with all prescribed antiretroviral therapy regimens.

More Important Details About REPRIEVE

The REPRIEVE has enrolled over 7,500 people with HIV at over 100 clinical sites across 11 countries (click here to see a complete list of sites). The trial will be conducted through the AIDS Clinical Trials Network and many other sites approved by the NIH Division of AIDS.


The REPRIEVE trial is funded by the National Heart Lung and Blood Institute at the National Institutes of Health, with significant support and collaboration from the National Institute of Allergy and Infectious Diseases (NIAID) through its Division of AIDS. In addition, Kowa Pharmaceuticals America, Inc. will be providing study drug and additional support.






This website, and related materials, applies only to REPRIEVE A5332. See list of participating sites here.


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