Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women with HIV: Insights from the REPRIEVE trial

By: Markella Zanni, Sara Looby and colleagues

Previous studies have shown that more advanced reproductive aging (transition through and past menopause) relates to the risk of heart disease. However, less is known about reproductive aging among women with HIV. REPRIEVE presents a unique opportunity to learn more about reproductive aging among women with HIV across
the globe.

In this study, the investigators examined the reproductive aging process among cisgender female participants (female participants whose gender identity matches their sex at birth) with HIV and the possible timing of the transition to menopause.

This was looked at based on two factors:

1. Menstrual history
2. Levels of a reproductive aging hormone called
   antimullerian hormone (lower levels of this
   hormone reflect increased reproductive aging)

The participants:

• 1,449 cisgender women total
• 45-55 years old
• 63% Black or African American
• 18% Asian

Results showed that women with HIV living in certain regions (including sub-Saharan Africa and Latin America and the Caribbean) and women with higher waist measurement had greater odds of having more advanced reproductive age. Age of menopause was typically in the age range of 49 to 51.

When REPRIEVE is completed, we will be able to look at how reproductive age relates to the risk of heart disease among women with HIV.

Read the full manuscript by clicking here.

The findings are from the REPRIEVE population at a specific point in time, these findings are descriptive and not intended to change clinical care, if you have questions about what you’ve read please talk to members of the REPRIEVE study team at your local site or a health care provider.