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April 3, 2024

A Closer Look at the New Statin Therapy Guidelines for Patients With HIV

By Kathleen V. Fitch, Marissa Diggs, and Steve Grinspoon Due to the remarkable strides in the management and support of PWH, life expectancy now almost parallels […]
March 14, 2024

Women with HIV need tailored advice on statins and heart disease risk

By Keith Alcorn The REPRIEVE study of pitavastatin for prevention of cardiovascular disease showed that statins reduced the risk of major cardiovascular events such as heart attack […]
March 13, 2024

Addressing Liver and Cardiovascular Disease among People with HIV and HIV Prevention During Pregnancy: Dr. Dieffenbach’s Second Update from CROI 2024

On Tuesday at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI), HIV.gov spoke with NIH’s Dr. Carl Dieffenbach about research on common health complications of […]
March 4, 2024

Tools Underestimate Cardiovascular Event Risk in People with HIV: NIH Trial Reveals Need for More Accurate Screening in Black People and Cisgender Women

The elevated cardiovascular disease risk among people with HIV is even greater than predicted by a standard risk calculator in several groups, including Black people and […]
February 28, 2024

Recommendations for Statins in People with HIV from the DHHS/ACC/AHA/HIVMA

The Department of Health and Human Services Guidelines Panel for the Use of Antiretroviral Agents in Adults and Adolescents with HIV (the Panel) has developed recommendations […]
January 22, 2024

REPRIEVE Will Forever Change Our Approach to Statin Use in People Living With HIV

By David Alain Wohl, MD While it’s not new, injected, implanted, or even prohibitively expensive, it is the medication studied in the most important HIV-related clinical […]
January 5, 2024

NEJM Journal Watch Infectious Diseases Top Stories of 2023

By Rajesh T. Gandhi The editors present their choices of the most important articles from the year. Read the full article here.
December 15, 2023

British Experts Recommend Statins for All HIV-Positive People 40 and Older

By Liz Highleyman The British HIV Association (BHIVA) now recommends that all people living with HIV who are ages 40 and older should be offered a statin […]
December 12, 2023

BHIVA rapid guidance on the use of statins for primary prevention of cardiovascular disease in people living with HIV

November 21, 2023 In cohort studies, compared to the general population or controls without HIV, people living with HIV are at greater risk of atherosclerotic cardiovascular […]
November 30, 2023

World AIDS Day: Research from Across Mass General Brigham

November 29, 2023 December 1 marks the 35th commemoration of World AIDS Day, an annual event that reminds us that HIV and HIV-related stigma remain public […]
November 16, 2023

Use of statins in individuals with HIV and low cardiovascular risk: the next stop along the route to optimized risk management

By Iulia Filip The puzzle of cardiovascular (CV) risk reduction in people with HIV (PWH) is a hard one to solve in the absence of CV risk […]
November 15, 2023

Pitavastatin lowers plaque volume, progression in lower-risk patients with HIV

By Erik Swain Pitavastatin lowered noncalcified plaque volume and reduced risk for plaque progression compared with placebo in patients with HIV at low to moderate risk […]
October 4, 2023

For people with HIV, statins show 35 percent drop in heart attack risk

By Linda Searing Although people living with HIV have a greatly increased risk for cardiovascular issues, such as blocked arteries, heart attacks and stroke, new research has found […]
September 12, 2023

For ‘Silver Tsunami’ With H.I.V., New Hope for Healthy Aging

By Benjamin Ryan A recent study showed that a statin drug significantly lowered the risk of heart attacks and strokes among middle-aged and older people with […]
August 17, 2023

Preventing HIV’s Collateral Cardiovascular Damage

People living with HIV have increased risk for cardiovascular disease (and other diseases of aging) earlier in life than those without HIV. In this episode of […]
August 4, 2023

Statins and HIV: how can the REPRIEVE findings be implemented in the real world?

By Liz Highleyman Findings from the landmark REPRIEVE trial, which tested a daily statin medication for people living with HIV, were presented on Monday at the 12th […]
August 4, 2023

Pitavastatin Prevented Cardiovascular Events in People with HIV

By Rajesh T. Gandhi A randomized trial demonstrates that even those PWH at low-to-moderate risk for cardiovascular disease benefit from starting pitavastatin. Read the full article […]
August 4, 2023

REPRIEVE Trial Highlights Shift in HIV Care from ID to General Medicine

By Paul Sax The biggest news this week at the 12th IAS Conference on HIV Science here in Brisbane, Australia, was the results of REPRIEVE, a large […]
July 26, 2023

‘Guideline-Changing’ Data Show Statin Cuts Cardiovascular Health Events Substantially in People With HIV

By Larry Buhl A triumphant mood was evident at a session of the 12th International AIDS Society (IAS) Conference on HIV Science during which a panel […]
July 26, 2023

Statin Cuts Cardiovascular Risk for People With HIV

By Liz Highleyman REPRIEVE trial finds pitavastatin reduced the risk of heart attack, stroke and other major cardiovascular events by 35%. Read the full article here.
July 26, 2023

A Statin a Day Keeps Heart Trouble Away for Those With HIV

By Cara Murez Heart disease is a high risk for people with HIV, but a new study finds that taking statins significantly reduces the risk of […]
July 26, 2023

Daily Statin Cuts Cardiovascular Risk in HIV

By Bianca Nogrady “I think the data are suggesting that it’s certainly in part due to the reduction in LDL — that is very important — […]
July 26, 2023

Statin Reduced Risk of Heart Disease in People With HIV

By Ed Susman The cholesterol-lowering agent pitavastatin (Livalo) as primary prevention reduced the risk of major adverse cardiovascular events (MACE) among people living with HIV, the […]
July 24, 2023

Statins reduce cardiovascular risk in people living with HIV, new global study finds

By Deborah Balthazar A statin a day reduces the risk of heart disease in younger people living with HIV, according to a new study published Sunday in the […]
July 24, 2023

Pitavastatin lowers risk of cardiovascular events in people living with HIV

By Liz Highleyman A widely used statin medication reduced the risk of heart attacks, strokes and other cardiovascular events when given to people with HIV who […]
July 24, 2023

Daily Statin Medication Reduces Risk of Major Cardiovascular Events by More Than One-Third in People Living with HIV

By Noah Brown The risk of cardiovascular diseases, including myocardial infarction and stroke, has been shown to be roughly twice as high in people living with […]
July 24, 2023

HIV patients face double the risk of heart disease. Taking a statin could help

By Giri Viswanathan Scientists have long known that people living with HIV face a higher risk of heart disease. The statin drug pitavastatin, however, might offer a […]
July 24, 2023

Daily statin reduces heart disease risk among adults living with HIV

A National Institute of Health-supported study found that statins, a class of cholesterol-lowering medications, may offset the high risk of cardiovascular disease in people living with […]
July 14, 2023

Statin use in people living with HIV

By Priya Venkatesan The REPRIEVE trial has shown a benefit of statins in reducing the risk of cardiovascular events in people living with HIV, but many […]
May 3, 2023

Daily Statin Trial for People With HIV Halted Early for Clear Benefit

By Emily Harris People with HIV and a low to moderate traditional risk of cardiovascular disease who took a daily 4-mg dose of pitavastatin reduced their risk […]
April 13, 2023

Statin Reduces Cardiovascular Risk for People With HIV

By Liz Highleyman Large trial finds that pitavastatin lowered the risk for major cardiovascular events by 35%. Read the full article here.
April 13, 2023

Statin Primary Prevention Trial in HIV Halted for Efficacy

By Megan Brooks An international clinical trial testing statin therapy for primary cardiovascular prevention in people living with HIV has been stopped early due to strong […]
April 13, 2023

REPRIEVE Stopped: Big MACE Reductions With Statins in HIV+ Subjects

By Shelley Wood HIV is merely a “risk modifier” in current guidelines; these results pave the way for a new primary-prevention indication for statins. Read the […]
March 16, 2023

INSTI Use Beyond Two Years Not Associated With Greater Weight Gain in Global REPRIEVE Study

By Barbara Jungwirth People living with HIV (PLWH) taking integrase strand transfer inhibitors (INSTIs) gained more weight during the first two years of that regimen than […]
March 13, 2023

New insights into how patient factors and COVID-19 infection affect antibody responses in people with HIV

Press Release from Massachusetts General Hospital Read the full feature here.
November 14, 2022

Diet Quality is Suboptimal or Poor in Large Proportion of Global Population with HIV

In Massachusetts General Hospital Advances in Motion Read the full feature here.
November 14, 2022

Sex-specific Mechanisms Contributing to Myocardial Infarction Risk Among People With HIV

In Massachusetts General Hospital Snapshot of Science Read the full newsletter here.
May 2, 2022

More Cardiac Abnormalities Seen in People Living With HIV

By Heather Boerner Read the full article here.
May 2, 2022

This Week in HIV Research: What Doesn’t Kill Us

By Barbara Jungwirth and Myles Helfand Read the full article here.
May 2, 2022

A Majority of People With HIV Have Asymptomatic COVID

By Liz Highleyman Read the full article here.
December 13, 2021

Significant differences exist in COVID-19 vaccination rates among people with HIV

By Caitlyn Stulpin Read the full article here.
December 13, 2021

International study reveals COVID-19 vaccination rates among people living with HIV

Rates are similar to the general population but vary across geographic regions. Read the full article here.
December 2, 2021

Coronary Plaque in People with Well-Controlled HIV and Low ASCVD Risk

The REPRIEVE study finds that many younger, asymptomatic adults with HIV have levels of plaque that persist despite low traditional risk of ASCVD. Caitlan Rossi, MedPage […]
October 29, 2021

NIH Statement on World AIDS Day 2020

In his #WorldAIDSDay statement, Dr. Fauci highlights how far we have come, how far we have yet to go, and acknowledges the important work of the […]
October 1, 2021

People With HIV Have High Levels of Inflammation and Coronary Plaque

White men and smokers are more likely to have arterial plaque despite low cardiovascular risk scores. Heather Boerner | POZ Read the full article here.
October 1, 2021

ACTG Announces Publication Of REPRIEVE Sub-Study In JAMA Network Open, Providing Insights Into Cardiovascular Disease Risk Among People Living With HIV

Nearly half of the participants (49%) had plaque in their arteries. ACTG Read the full article here.
October 1, 2021

HIV and Coronary Artery Plaque

Researchers ID condition with potential CVD implications. Randy YoungMGH News and Public Affairs Read the full article from HMS here.
September 3, 2020

Major Global Study of HIV’s Ties to Heart Disease Is a Data Goldmine

The REPRIEVE study, which is primarily looking at a statin’s effect on cardiovascular disease, is shedding light on many other mysteries. Benjamin RyanEditor at Large, POZ […]
September 3, 2020

Large NIH Clinical Trial Illuminates Long-Term Health Effects of HIV

Initial data from a large NIH-supported clinical trial offer a detailed look at the health status of people aging with HIV around the world. With 7,770 […]
July 22, 2020

Six manuscripts, plus an introduction piece, published as a supplement in The Journal of Infectious Diseases!

The suite of manuscripts, utilizing key baseline data from the REPRIEVE trial, highlight the impact and prevalence of critical comorbidities among a global cohort of people […]
July 22, 2020

Initial data from the landmark REPRIEVE study on HIV and heart disease highlights the multiple health risks among a population that’s living longer

The impact and prevalence of heart disease and other critical comorbidities on an aging global population with human immunodeficiency virus (HIV) have emerged from a suite […]
October 5, 2018

Prism Health Teams with Harvard for Study

People living with HIV are developing heart disease at twice the rate of the general population, and Prism Health and Harvard Medical School want to know […]
September 10, 2018

Clinical trial seeks to prevent heart disease in those living with HIV

An international clinical trial, which is looking for effective ways to prevent heart disease in those living with HIV, has hit 7,000 participants. “It’s a major […]
May 7, 2018

Why Does HIV Pose a Greater Threat to Women’s Hearts?

HIV-related heart disease is a leading cause of death among people living with HIV — even when they are on consistent, effective HIV treatment. Researchers are […]
February 14, 2018

Happy Heart Month: What People Living with HIV Should Know

Today marks not just a time to exchange valentines and chocolates, but also the midpoint of American Heart Month(link is external). Did you know people living with […]
December 22, 2017

Exploring Barriers for Women in HIV Clinical Research With REPRIEVE

Throughout history, women have been excluded from clinical research studies, resulting in a dearth of knowledge about the effect that drugs might have on different sexes. […]
December 1, 2017

Cardiovascular disease: the next great challenge for HIV care

In the first World AIDS Day in 1988, the outlook was bleak for people living with this strange, new, and deadly disease. Few could imagine the […]
September 18, 2017

NIAID Supports Research Towards Healthy Aging for People Living with HIV

Today marks the 10th National HIV/AIDS and Aging Awareness Day. This annual observance brings attention to the unique social and health-related challenges of older people living […]
September 18, 2017

Preventing HIV-Related Heart Disease

As people living with HIV grow older, heart disease is emerging as a major public health problem despite effective treatments that suppress the virus and extend […]
June 17, 2017

HIV-1–Associated Atherosclerosis

Cardiovascular disease, including atherosclerosis and atherosclerosis-associated complications, is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV) patients in the post-antiretroviral therapy era. […]
May 28, 2017

Study explores way to stave off heart attacks in HIV patients

People infected with HIV can now live long, healthy lives — so long as they don’t have a heart attack. Cardiovascular problems among HIV patients are emerging as […]
April 24, 2017

New Findings Highlight the Potential Utility of Pitavastatin for People Living with HIV in Support of the REPRIEVE Trial

Stemming from the INTREPID Trial, three recently published papers give credence to pitavastatin’s ability to lower cholesterol and dampen inflammation in people living with HIV.
April 20, 2017

REPRIEVE is featured on Expresso morning show in South Africa

For years Medical researchers, government agencies and health institutes have been looking at ways to improve health outcomes of individuals living with HIV/AIDS. With the advent […]
March 8, 2017

Women are leading the way in HIV research

There is a saying in South Africa: Wathint’ abafazi, wathint’ imbokodo. You strike the women, you strike the rock. On International Women’s Day, we want to […]
February 28, 2017

US trial seeks HIV-positive South Africans for study

A US-funded study is recruiting South Africans to help find a way to prevent heart disease among HIV-positive people. Someone with HIV can have more than […]
February 22, 2017

Spotlight On: #HEARTHEALTH and People Living With HIV

February is heart health month, a perfect time to focus our attention on an important area of concern in the HIV community: cardiovascular health. People living […]
February 14, 2017

This February, Take Heart: NIH is Committed to Preventing HIV-Related Heart Attacks and Strokes

Antiretroviral therapy (ART) has transformed HIV infection from an almost-always fatal disease to what is now a manageable, chronic health condition. Today, a person diagnosed with […]
February 13, 2017

How to Make Preventing Heart Disease in HIV Fun and Exciting: The REPRIEVE Trial

The people researching cardiovascular disease in HIV have quite the challenge.Because when you think about it for a second, we HIV treaters are a pretty spoiled bunch […]
February 13, 2017

Campaign Launched to Get More Women Into HIV Heart Health Study

People with HIV seldom die of AIDS-related opportunistic infections anymore. Thanks to modern medicine called highly active antiretroviral therapy, or HAART, many people diagnosed with HIV […]
February 9, 2017

Can Statins Cut Heart Disease Risk in HIV Patients?

February is American Heart Month, and traditionally a time when organizations such as the American Heart Association ramp up initiatives to promote awareness of heart disease. […]
February 2, 2017

Should People With HIV Take a Statin?

HIV is linked to a higher heart disease risk. Research suggests statins can help. But definitive proof likely won’t come for another three years. Even when […]
December 1, 2016

The REPRIEVE Trial: The Last Word on Cardiovascular Disease in HIV-positive Persons (Hopefully)

Your 50 Year-old, female, HIV-positive patient, presents for a follow-up visit. She has heard that the risk of cardiovascular disease is increased among people living with […]
December 1, 2016

NIH Statement on World AIDS Day

This year, the world marked the 35th anniversary of the first published reports of what would come to be known as HIV/AIDS. This disease has wrought […]
November 23, 2016

Stopping a silent killer

“I had no idea that since I have HIV, I may be twice as likely to have a heart event compared to the general population,” said Frank […]
September 29, 2016

Woman-Centric Research and Why it’s Time to Listen to the Ladies

Earlier this month, AVAC hosted a webinar to explain and explore the complex issues of hormonal contraceptives and HIV risk in light of a new analysis that is generating […]
September 13, 2016

A Reprieve For Women: Embracing Inclusive Scientific Research

Historically, understanding a woman’s unique biology and developing optimal interventions for women has been somewhat of a blind spot for medical research. For much of the […]
June 17, 2016

REPRIEVE Trial Investigators Launch “Follow YOUR Heart” Campaign for Women Living with HIV

Research shows that women are often underrepresented in HIV clinical trials. In fact, astudy recently published in the Journal of Acquired Immune Deficiency Syndromes found that less […]
June 15, 2016

HIV and Heart Disease – NIH Explores the Connection

HIV-positive men and women can now live longer than ever before. A 2013 study found that a newly diagnosed 20-year-old on effective antiretroviral therapy (ART) can […]
April 29, 2016

Researchers evaluating HIV’s hidden heart threats

Human immunodeficiency virus infection is no longer the death sentence it was 30 years ago, but HIV-infected adults may face a new health hurdle – heart […]
April 14, 2016

REPRIEVE Heart Disease Trial Enrolls 1,200 Seeks Female Participants

The REPRIEVE trial, which will test a sort of “PrEP for heart disease” among 6,500 people with HIV at sites around the world, has already enrolled […]
March 30, 2016

Clinical trial addresses HIV and cardiovascular risks

Researchers at two area universities are among those participating in a nationwide clinical trial focused on HIV-related cardiovascular disease. University of Illinois at Chicago and Northwestern […]
March 4, 2016

Study looks at HIV/AIDS heart risk

Several Boston-area doctors will serve as primary investigators in a worldwide study on heart disease among HIV/AIDS patients — just one deadly upshot of an illness […]
January 6, 2016

New med Could Prevent Heart Disease in People with HIV

Call it a PrEP to protect against heart disease in people with HIV.A large, multi-site clinical trial dubbed REPRIEVE has begun enrolling across the U.S. and […]
December 14, 2015

Landmark Trial to Examine Cardiovascular Treatment in HIV Patients

Over the course of their careers, many clinicians have seen HIV/AIDS progress from extremely high short-term mortality to chronic, long-term disease management. As HIV patients are […]
December 1, 2015

World AIDS Day 2015

Leadership from REPRIEVE: Randomized Trial to Prevent Vascular Events in HIV, would like to recognize World AIDS Day as a time to remember those we have lost to HIV/AIDS and also recognize the progress that has been made to help people with HIV live longer, healthier lives.
November 2, 2015

Sponsored by National Institutes of Health, the largest clinical trial ever focused on HIV-related cardiovascular disease is still seeking poz participants

As HIV-positive people continue living longer due to highly active antiretroviral therapy, cardiovascular disease has become a growing concern.  According to the National Institute of Allergy and […]
October 1, 2015

HIV-Related Cardiovascular Disease, Statins, and the REPRIEVE Trial

HIV infection is associated with increased cardiovascular disease (CVD), and increased rates of myocardial infarction and stroke have been observed in HIV-infected individuals. After traditional risk […]
October 1, 2015

Getting to the Heart of the Matter

HIV raises the risk of heart disease. What can you do to lower that risk?People with HIV are at a greater risk for heart disease than […]
August 18, 2015

Exploring Statins to Decrease HIV-Related Heart Disease Risk

Antiretroviral therapy (ART) has been a lifeline for untold numbers of patients with HIV. But as mounting evidence shows the infection may increase their risk of […]
July 30, 2015

REPRIEVE featured in JAMA

JAMA article highlights REPRIEVE trial for studying ways to prevent HIV-Related Heart Disease! Individuals living with HIV are at increased risk of heart disease.
July 27, 2015

REPRIEVE for Heart Disease in HIV

REPRIEVE was recently featured online in POZ. Click here to read more!
May 27, 2015

REPRIEVE and Washington University Featured in the St. Louis Post-Dispatch

Washington University's participation in the REPRIEVE trial is featured in the St. Louis Post-Dispatch!
May 1, 2015

Novel mechanisms and potential treatment strategies for CVD in HIV patients

Epidemiological studies suggest cardiovascular disease, including myocardial infarction and stroke, are increased 50% to 100% among HIV patients compared with non-HIV patients. Moreover, data suggest cardiovascular […]
April 24, 2015

Exciting News from MGH About the REPRIEVE Trial

Exciting news from Massachusetts General Hospital about the REPRIEVE trial!
April 15, 2015

NIH Announces REPRIEVE Trial Launch

NHLBI and NIAID announce launch of the REPRIEVE Trial:
March 13, 2015

Dr. Monica Shah Publishes on High Priority Research Including REPRIEVE Trial

Please see attached link to article “Stimulating High Impact HIV-Related Cardiovascular Research: Recommendations From a Multidisciplinary NHLBI Working Group on HIV-Related Heart, Lung, and Blood Disease” by Dr. Monica Shah published in the February 24, 2015 issue of the Journal of the American College of Cardiology.
March 11, 2015

Importance of REPRIEVE Trial Highlighted at CROI 2015

REPRIEVE Trial highlighted by Dr. Steven Grinspoon, Co-PI of the REPRIEVE Trial at HIV Conference/CROI 2015, in Seattle, WA.
March 10, 2015

Dr. Steven Grinspoon is Interviewed about REPRIEVE

At the 2015 Conference on Retroviruses and Opportunistic Infections (CROI Conference) in Seattle, Washington, Dr. Steven Grinspoon, Co-PI of the REPRIEVE trial, is interviewed on the topic of his plenary presentation: “Cardiovascular Disease in HIV Patients: An Emerging Paradigm and Call to Action”.
October 27, 2014

MGH: Can statin treatment cut cardiovascular risk in HIV-infected patients?

BOSTON – A nationwide study based at Massachusetts General Hospital (MGH) will investigate, for the first time, whether treatment with a statin drug can reduce the elevated risk of cardiovascular disease in individuals infected with the human immunodeficiency virus (HIV).
October 22, 2014

NY Times: “Heart Trouble Early and Often in H.I.V. Patients”

He was 29 when he began antiretroviral therapy.He was 43 when he had a heart attack.“I felt fluttery,” he said. “Weird and fluttery. It went away. I ignored it. A week later, it came back, and this time I felt something in my arm too. I was too stupid to call an ambulance. I got in a cab and went to the hospital.”