How can people with HIV (PWH) protect their heart health?
People with HIV (PWH) have a higher risk of heart disease compared to people without HIV. REPRIEVE, which stands for The Randomized Trial to Prevent Vascular Events in HIV, is the first large-scale randomized clinical research trial to test a strategy for heart disease prevention in this population. Specifically, REPRIEVE tested whether a daily dose of a statin (pitavastatin calcium) reduced major heart disease events such as heart attacks and strokes among a globally representative population of PWH. REPRIEVE was stopped early, after about an average of 5 years of follow-up, after revealing that pitavastatin (vs. placebo) was effective. Taking pitavastatin reduced major heart disease events by 35% and reduced major heart disease events or death from any cause by 21% compared to placebo.
The REPRIEVE Team has created a number of educational resources including a graphical abstract, participant guidance for statin use after REPRIEVE, a plain language summary of the primary REPRIEVE publication, and more. Click below to access these resources!
REPRIEVE Graphical Abstract
What was the purpose of the REPRIEVE Trial? Who participated in the trial, and what medication was tested? What were the results of the trial? These questions and more are answered in this graphical abstract which summarizes the main points of the trial and its findings!English Spanish Portuguese French Canadian
Guidelines for Statin Therapy in People with HIV
REPRIEVE Primary Manuscript Plain Language Summary*
The risk of heart disease is higher among people with HIV (PWH) compared to people without HIV, including among younger individuals with low-to-moderate predicted heart disease risk. Researchers do not fully understand why this risk is higher, but they believe it could be related to both traditional heart disease risk factors, like smoking, and to HIV-related factors, like inflammation. Though having HIV has been considered to increase the risk of heart disease, until now there has been no proven treatment to prevent heart disease in PWH.English Spanish Portuguese Thai Afrikaans French French Canadian Haitian Creole Sesotho Xhosa Zulu