July 17, 2023

Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People with HIV in the REPRIEVE Cohort

Abstract Background Pericoronary adipose tissue (PCAT) may influence plaque development through inflammatory mechanisms. We assessed PCAT density, as a measure of pericoronary inflammation, in relationship to […]
July 10, 2023

Associations of Muscle Density and Area with Coronary Artery Plaque and Physical Function

Abstract Objective Skeletal muscle quality and mass are important for maintaining physical function during advancing age. We leveraged baseline data from REPRIEVE to evaluate whether paraspinal muscle density […]
April 5, 2023

Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV

Abstract Background Mechanisms contributing to COVID-19 severity in people with HIV (PWH) are poorly understood. We evaluated temporal changes in plasma proteins following SARS-CoV-2 infection and […]
March 1, 2023

Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People with Treated HIV

Abstract Inflammasome activation is increased in people with HIV (PWH), but its relationship with coronary plaque is poorly understood in this setting. In a large HIV […]
February 27, 2023

Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: a Longitudinal Analysis of REPRIEVE data

Abstract Weight gain with longer-term INSTI-based regimens remains unknown. Over 2-years of follow-up in REPRIEVE, INSTI use was associated with weight gain among those on an […]
February 27, 2023

Impact of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV

Abstract People with HIV (PWH) appear at higher risk for suboptimal pathogen responses and worse COVID-19 outcomes, but the effects of host factors and COVID-19 on […]
November 30, 2022

The importance of methods for site performance evaluation in REPRIEVE, a longitudinal, global, multicenter trial

Abstract Background REPRIEVE, the Randomized Trial to Prevent Vascular Events in HIV, is a multicenter, primary prevention trial evaluating whether a statin can prevent major cardiovascular […]
November 30, 2022

Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV

Abstract Objective To investigate relationships between Life’s Simple 7 (LS7), an assessment of cardiovascular health (CVH), and coronary plaque among people with HIV (PWH). Methods Coronary […]
September 27, 2022

Sex-Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation among People with HIV in the U.S.

Abstract Background Among people with HIV (PWH), sex-differences in presentations of atherosclerotic cardiovascular disease (ASCVD) may be influenced by differences in coronary plaque parameters, immune/inflammatory biomarkers, […]