JID

REPRIEVE Journal of Infectious Disease Supplement | 2020

Critical Comorbidities in the Modern Antiretroviral Era: Baseline Demographic, Metabolic, and Immune Characteristics of the Global REPRIEVE Trial Population

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CVD Risk Plain Language Summary

Heart Disease Risk and Heart Health Among People with HIV Eligible for Primary Prevention | 2021

Poor CV health by LS7 was common among REPRIEVE participants, regardless of PCE. This suggests a critical and independent role for lifestyle interventions in conjunction with conventional treatment to improve CV outcomes in PWH.

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Assessment of Coronary Artery Disease with Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults with HIV | 2021

These findings suggest that people with HIV at low to moderate risk of cardiovascular disease have a significant prevalence of coronary plaque associated with inflammation and immune activation markers.

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Assessment of Obesity and Cardiometabolic Status by Integrase Inhibitor Use in REPRIEVE | 2021

Differences in weight and waist circumference associated with INSTI use are (1) not uniform across people with human immunodeficiency virus, (2) greatest among women and nonwhites, and (3) concentrated at the upper tails of weight distribution. These data identify at-risk subgroups for whom long-term cardiovascular disease outcomes should be carefully assessed.

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Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV | 2021

Prolonged QTc is common among male, Asian, and REPRIEVE participants with higher viral loads. These relationships warrant future investigation of linkages to ensuing CVD events among PWH.

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COVID-19 Vaccination Rates in a Global HIV Cohort | 2021

The global probability of COVID-19 vaccination through end of July 2021 was 55% among REPRIEVE participants with rates varying substantially by Global Burden of Disease (GBD) superregion. Among PWH, factors associated with COVID-19 vaccination included residence in high-income regions, age, white race, male sex, body mass index, and higher cardiovascular risk.

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Geographical Differences in the Self-Reported Functional Impairment of People with HIV and Associations with Cardiometabolic Risk | 2022

Over 1/3 of middle-aged and older PWH in a global cohort across diverse GBD regions demonstrate functional impairments. The associations between DASI and cardiometabolic risk suggest that a measure of functional status may improve risk prediction; these longitudinal associations will be further investigated over REPRIEVE trial follow-up.

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Factors Associated with Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People with HIV on Antiretroviral Therapy

Factors associated with oxLDL and sCD14, two key indices of immune-mediated CVD risk, differ. Future studies will elucidate ways in which medications (e.g. statins) and behavioral modifications influence sCD14/oxLDL and the extent to which dampening of these markers mediates CVD-protective effects.

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Asymptomatic SARS-CoV-2 Infection is Common among ART-treated People with HIV

Asymptomatic SARS-CoV-2 infection is common among ART-treated PWH globally. We determined that 60% of infections in PWH were asymptomatic. HIV clinicians must remain vigilant about COVID-19 testing among PWH to identify asymptomatic cases.

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Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy

Distinct immune and inflammatory pathways are differentially associated with subclinical CAD phenotypes among PWH. This comprehensive set of targets should be further investigated to reduce atherosclerosis and ASCVD in PWH.

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Diet Quality by Global Burden of Disease Region in Adults with HIV at Low to Moderate Traditional Cardiovascular Disease Risk in REPRIEVE

Poor diet is an important modifiable risk factor for chronic conditions that are common among people with HIV. This analysis found that there were important variations in diet quality by geographic region, and diet was suboptimal or poor for 42% of all participants. Poor diet is an important risk factor for heart disease and can be improved among a large proportion of people with HIV.

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CMV CAD PLS

Cytomegalovirus Immunoglobulin G (IgG) Titer and Coronary Artery Disease in People With Human Immunodeficiency Virus (HIV)

Cytomegalovirus (CMV) is a common viral infection among people all over the world, especially those with HIV. It is thought that among people living with HIV (PWH), prior CMV infection may lead to increased inflammation. Additionally, prior CMV infection has been linked to an increased risk of heart disease among PWH. In this analysis, we looked for associations between prior CMV infection and heart disease using CMV IgG titer (antibody response to CMV) and coronary computed tomography angiography (CTA) among PWH enrolled in the REPRIEVE trial.

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Sex-Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation among People with HIV in the U.S.

People with HIV on antiretroviral therapy (ART) face increased risks of heart disease as compared to people without HIV, and drivers of heart disease risk are believed to differ by sex. The goals of this study were to examine sex-differences in possible drivers of heart disease risk among people with HIV participating in a substudy of the REPRIEVE trial.

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