Marissa Diggs, Author at REPRIEVE Trial

March 1, 2023

Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People with Treated HIV

Abstract Inflammasome activation is increased in people with HIV (PWH), but its relationship with coronary plaque is poorly understood in this setting. In a large HIV […]

February 27, 2023

Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: a Longitudinal Analysis of REPRIEVE data

Abstract Weight gain with longer-term INSTI-based regimens remains unknown. Over 2-years of follow-up in REPRIEVE, INSTI use was associated with weight gain among those on an […]

February 27, 2023

Impact of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV

Abstract People with HIV (PWH) appear at higher risk for suboptimal pathogen responses and worse COVID-19 outcomes, but the effects of host factors and COVID-19 on […]

November 30, 2022

The importance of methods for site performance evaluation in REPRIEVE, a longitudinal, global, multicenter trial

Abstract Background REPRIEVE, the Randomized Trial to Prevent Vascular Events in HIV, is a multicenter, primary prevention trial evaluating whether a statin can prevent major cardiovascular […]

November 30, 2022

Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV

Abstract Objective To investigate relationships between Life’s Simple 7 (LS7), an assessment of cardiovascular health (CVH), and coronary plaque among people with HIV (PWH). Methods Coronary […]

November 14, 2022

Pathophysiology and management of cardiovascular disease in patients with HIV

Results from several studies have suggested that people with HIV have an increased risk of cardiovascular disease, especially coronary heart disease, compared with people not infected […]

November 14, 2022

Inflammation, immune activation, and cardiovascular disease in HIV

Cardiovascular disease is one of the leading causes of morbidity and mortality in people living with HIV. Several epidemiological studies have shown an increased risk of […]

November 14, 2022

Epidemiology of ischemic heart disease in HIV

Purpose of review The purpose of this review is to summarize and synthesize recent data on the risk of ischemic heart disease (IHD) in HIV-infected individuals. […]

November 14, 2022

HIV-Related Cardiovascular Disease, Statins, and the REPRIEVE Trial

HIV infection is associated with increased cardiovascular disease (CVD), and increased rates of myocardial infarction and stroke have been observed in HIV-infected individuals. After traditional risk […]